Renin-angiotensin aldosterone profile before and after angiotensin-converting enzyme-inhibitor administration in dogs with angiotensin-converting enzyme gene polymorphism     

Darcy Adin  Clarke Atkins  Oliver Domenig  Teresa DeFrancesco  Bruce Keene  Sandra Tou  Joshua A. Stern  Kathryn M. Meurs 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2020,34(2):600-606

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Natural hybridization between two sibling species of Anolis lizards: chromosome cytology     

G C Gorman  L Atkins 《Science (New York, N.Y.)》1968,159(821):1358-1360

The Lesser Antillean lizards Anolis trinitatis and Anolis aenous were both apparently introduced to Trinidad where they are hybridizing. The parental species have 36 and 34 chromosomes, respectively. Hybrids have 35 chromosomes. Meiosis in hybrids is abnormal. There is an accumulation of cells at metaphase I, and poor homolog pairing, characterized by a low frequency of chiasmata and numerous univalents.  相似文献   

Pharmacokinetic and Pharmacodynamic Properties of Conventional and CD-Formulated Diltiazem in Cats   总被引：2，自引：1，他引：1  

Lynetta M. Johnson  Clarke E. Atkins  Bruce W. Keene  Stephen A. Bai 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1996,10(5):316-320

The IV and apparent steady-state kinetics of diltiazem HCI (DLT) and slow-absorption long-acting diltiazem (CD) given PO were investigated in cats. The effects of PO diltiazem on heart rate and PR interval were also studied. Plasma diltiazem concentrations were determined by ultraviolet high-performance liquid chromatography (UV-HPLC), using vera-pamil as the internal standard. Heart rate and PR interval determinations were evaluated over a 24–hour period for the PO formulations and compared with values under diltiazem-free conditions. The mean systemic clearance and apparent volume of distribution of IV diltiazem were 15.0 mL/min/ kg and 2.70 L/kg, respectively. The elimination half-life of diltiazem after IV and PO DLT administration were approximately 120 minutes. In contrast, the terminal half-life of CD was 460 minutes. The mean apparent bioavailability of DLT PO was 71%, which was significantly higher than that observed with CD (36%). Heart rate and PR intervals in cats receiving the 2 formulations at steady-state were not different from those measured in the drug-free state. We conclude that DLT at 1 mg/kg PO tid and CD at 10 mg/kg PO sid provide plasma concentrations that are known to have pharmacodynamic effects in other species.  相似文献   

Morphometric analysis of growth retardation in fetal lambs following experimental infection of pregnant ewes with Border Disease virus     

J.F Caffrey  A.M Dudgeon  W.J.C Donnelly  B.J Sheahan  G.J Atkins 《Research in veterinary science》1997,62(3):245

The onset of growth retardation was investigated in fetal lambs following experimental infection of pregnant ewes with Border Disease virus ( ) on day 53 of pregnancy. Fetuses from control and infected ewes were harvested at weekly intervals between day 60 and day 95 of gestation and morphometric studies were completed on tibial radiographs and tibial growth cartilage metaphyseal junctions. Mean tibial areas were significantly reduced (P<0·01) in fetuses from infected ewes at 35 and 42 days after infection and growth cartilage metaphyseal junctions were less mature in fetuses from infected ewes at 42 days after infection. Positive immunostaining for BDV antigen was demonstrated in the brains of all fetuses from infected ewes between 14 and 42 days after infection. Attempts to demonstrate BDV antigen in bone proved unsuccessful. It is concluded that intrauterine growth retardation is an early manifestation of BDV infection in lambs and that the process is initiated shortly following infection of the fetus.  相似文献   

The diagnosis of feline heartworm infection.     

C Atkins 《Journal of the American Animal Hospital Association》1999,35(3):185-187

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Effect of aspirin, furosemide, and commercial low-salt diet on digoxin pharmacokinetic properties in clinically normal cats     

C E Atkins  P S Snyder  B W Keene 《Journal of the American Veterinary Medical Association》1988,193(10):1264-1268

Steady-state serum digoxin concentration ([digoxin]) was measured for 48 hours in 6 healthy cats after they were treated with digoxin tablets (0.01 mg/kg of body weight, q 48 h) for 10 days and again after concurrent treatment of identical duration with orally administered digoxin, aspirin (80 mg, q 48 h), furosemide (2 mg/kg, q 12 h), and a commercial low-salt diet. The concurrent treatment substantially altered digoxin pharmacokinetic properties, with a resultant increase in peak (mean +/- SEM; from 2.1 +/- 0.35 to 3.3 +/- 0.6 ng/ml), 8-hour (from 1.4 +/- 0.35 to 2.5 +/- 0.64 ng/ml), and 48-hour mean (from 1.1 +/- 0.22 to 2.2 +/- 0.57 ng/ml) serum [digoxin]; an increase in the number of hours during which serum [digoxin] was in the toxic range (from 3 +/- 1.7 to 24.7 +/- 9.8 h); and a decrease in oral clearance (from 0.15 +/- 0.04 to 0.08 +/- 0.02 L/h.kg). Of these differences, all but the 8-hour serum [digoxin] were significant at P less than 0.05. Similar sampling procedures were performed in 3 cats after administration of digoxin alone (0.01 mg/kg, q 48 h) until steady-state conditions were reached (10 days) and again after an additional 10 days of treatment. Differences were not noticed in digoxin pharmacokinetic properties. Eight-hour serum [digoxin] was shown to correlate closely with the mean serum [digoxin] at steady-state conditions when digoxin was administered every 48 hours. Variation in digoxin pharmacokinetic properties was noticed between cats.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

Clinical, biochemical, acid-base, and electrolyte abnormalities in cats after hypertonic sodium phosphate enema administration   总被引：2，自引：0，他引：2  

C E Atkins  R Tyler  P Greenlee 《American journal of veterinary research》1985,46(4):980-988

Ten clinically healthy cats were allotted into 2 groups. Group A was given the low (60 ml), and group B was given the high (120 ml) recommended dose of a commercial hypertonic sodium phosphate enema. Enema retention was enforced. All cats developed clinical and/or laboratory abnormalities, with group B cats being more severely affected. Clinical signs that occurred rapidly included depression, ataxia, vomition, bloody diarrhea, mucous membrane pallor, and stupor; tetany was not seen. One cat in group B died. Laboratory abnormalities included hypernatremia, hyperphosphatemia, hypocalcemia, hyperglycemia, calculated hyperosmolality, and metabolic acidosis with high anion gap probably due to hyperlacticacidemia. There were no significant gross or microscopic lesions associated with enema administration. Therefore, the use of hypertonic sodium phosphate enema at recommended doses is potentially dangerous to cats.  相似文献   

Early Development and Putative Primordial Germ Cells Characterization in Dogs     

DS Martins  CE Ambrósio  NZ Saraiva  CV Wenceslau  AC Morini  I Kerkis  JM Garcia  MA Miglino 《Reproduction in domestic animals》2011,46(1):e62-e66

Previously, three distinct populations of putative primordial germ cells (PGCs), namely gonocytes, intermediate cells and pre‐spermatogonia, have been described in the human foetal testis. According to our knowledge, these PGCs have not been studied in any other species. The aim of our study was to identify similar PGC populations in canine embryos. First, we develop a protocol for canine embryo isolation. Following our protocol, 15 canine embryos at 21–25 days of pregnancy were isolated by ovaryhysterectomy surgery. Our data indicate that dramatic changes occur in canine embryo development and PGCs specification between 21 to 25 days of gestation. At that moment, only two PGC populations with distinct morphology can be identified by histological analyses. Cell population 1 presented round nuclei with prominent nucleolus and a high nuclear to cytoplasm ratio, showing gonocyte morphology. Cell population 2 was often localized at the periphery of the testicular cords and presented typical features of PGC. Both germ cell populations were positively immunostained with anti‐human OCT‐4 antibody. However, at day 25, all cells of population 1 reacted positively with OCT‐4, whereas in population 2, fewer cells were positive for this marker. These two PGCs populations present morphological features similar to gonocytes and intermediate cells from human foetal testis. It is expected that a population of pre‐spermatogonia would be observed at later stages of canine foetus development. We also showed that anti‐human OCT‐4 antibody can be useful to identify canine PGC in vivo.  相似文献   

'We're not told why--we're just told': qualitative reflections about the Western Australian Go for 2&5® fruit and vegetable campaign     

Carter OB  Pollard CM  Atkins JF  Marie Milliner J  Pratt IS 《Public health nutrition》2011,14(6):982-988

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关于内蒙古大兴安岭林区实施森林抚育补贴项目的探讨   总被引：2，自引：0，他引：2  

策日格 《内蒙古林业调查设计》2011,(4):9-11,15

文章通过对内蒙古大兴安岭林区实施森林抚育补贴项目的背景、必要性的分析,论述了森林抚育是促进林区生态、经济和社会协调发展的有力措施。  相似文献